Clinical Trials by Geographic Location

3 months – 5 years

Near-infrared Spectroscopy and Electroencephalography to Assess Cortical Activation During Motor Tasks in Infants and Toddlers With and Without Cerebral Palsy

• Purpose: To learn more about how infants and young children with and without cerebral palsy use their brain to move their arms and legs.
• Protocol: Participants will have at least 1 study session. Children who are not yet walking on their own are invited to come for multiple visits, no more than one per month as their walking progresses (all optional). Sessions last approximately 2-3 hours. We will collect data using EEG responses, and kinematic and/or kinetic, force plate, wearable sensors, and/or electromyography (EMG) recordings will be  during the performance of self-initiated motor tasks. Additionally, we will evaluate brain and motor responses to devices that aim to make movement easier for infants and children who may have difficulty initiating or performing these movements without assistance.
• Criteria: Diagnosis of CP; or at high risk for CP or children without CP
• Location: NIH, Bethesda, MD
• Contact: Mayra J Medrano, (301) 451-7529, mayra.medrano@nih.gov, Diane L Damiano, Ph.D, 301-451-7544, damianod@cc.nih.gov

4 months – 13 months

Telemedicine in Early Childhood Constraint Therapy in Cerebral Palsy

• Purpose:  To test whether a proven safe and effective intervention to improve hand and arm function (called APPLES) can be as successful when it is done through a combination of in person and tele-health video calls.
• Protocol: Infant participants with cerebral palsy will be randomized to one of three treatment groups over a 12 week period of time:1) The APPLES intervention via telehealth (APPLES-tele) followed by a parent-centered approach (PCA) intervention; 2) The PCA intervention followed by the APPLES-tele intervention; 3) Standard of care (after 6-weeks you can then choose what program you prefer). The study is done as a telehealth program in your home and requires 2 to 3 total in-person visits to complete assessments and answer questions about your child.Outcome measures will be standardized assessments of hand/arm function and validated parent-report measures of infant motor activity.
• Criteria: High Risk for CP or Diagnosis of CP with upper Limb Asymmetry
• Location: US, Ireland
• Contact: Jen Lyman, text only 678-476-5332, jlyman@emory.edu

5 months -12 months

Virtual study: Measuring everyday experience in infants at risk for cerebral palsy

• Purpose: To learn more about everyday activity in infants at risk for cerebral palsy
• Protocol: Caregivers will receive text messages 10 times throughout their day (8 days total) with a link to a quick survey about their child’s current activities. The survey will take about 1 minute to complete each time.
• Criteria: Infants with cerebral palsy, perinatal brain injury, or documentation of clinical assessments (General Movements Assessment, HINE) indicating high risk for CP
• Location: Virtual (families participate from their homes anywhere in the United States)
• Contact: Kari Kretch, PT, DPT, PhD, 323-442-0191, kretch@usc.edu, Lab website

5 months to 18 months (adjusted for prematurity for those 37 weeks or less)

Promoting Upright Mobility in Infants with CP Using a Robotic "BabyG" Unweighting System 

• Purpose: To evaluate the effects of 12 weeks of mobility training while in a computer-controlled (robotic) unweighting system (BabyG) on motor development rate in infants diagnosed with or at high risk for cerebral palsy (CP) who are less than 18 months old at enrollment compared to a 12-week period when they are not participating in training.
• Protocol:   BabyG training and 12 weeks without. Training will be 90 minutes per week: either two 45-minute sessions or three 30-minute sessions. All participants will undergo tests during the 24 weeks.
• Criteria:  Diagnosis of CP or high risk of CP;  Ability to push up on extended arms in prone for at least 10 seconds or demonstrates an interest in moving from one place to another by rolling, scooting or other means. 
• Location:  NIH, Bethesda, MD
• Contact: Mark N Dhason, (301) 451-7529, mark.dhason@nih.gov

3 years – 17 years

Evaluating Long-term Use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to Improve Gait in Children with Movement Disorders

• Purpose: To learn whether a robotic device worn on the legs can improve walking ability in those with a gait disorder.
• Protocol: This study takes place over 1 year and is split into three 12-week phases. During 1 phase, participants will continue with their standard therapy. In phase 2, participants will work with the exoskeleton in a lab setting. Their legs will be scanned to create an exoskeleton with a customized fit. The exoskeleton operates in different modes: in exercise mode, it applies force that makes it difficult to take steps; in assistance mode, it applies force meant to aid walking; in combination mode, it alternates between these two approaches. In phase 3, participants take the exoskeleton home where they walk in the device at least 1 hour per day, 5 days per week, for 12 weeks. Walking ability will be retested after each phase.
• Criteria: Diagnosis of CP; Able to walk 10 feet with or without assistance
• Location: NIH, Bethesda, MD
• Contact: Mayra J Medrano, 301-451-7529, mayra.medrano@nih.gov, Thomas C Bulea, M.D, 301-451-7533, buleatc@mail.nih.gov

3 years - 25 years

Investigating New Methods to Study Movement in Children and Young Adults With Movement Disorders

• Purpose: To test new technologies to measure peoples movements and brain function while they move with and without a robotic exoskeleton.
• Protocol: Participants will have 3 to 5 clinic visits in 2 months. Participants will be fitted with an exoskeleton that will be worn on one of their legs. At each visit, participants will be asked to move their wrist, ankle, and knee while the following measurements are taken: Ultrasound, Electroencephalography (EEG), Electromyography (EMG), Functional electrical stimulation (FES).  Participants will also walk on a treadmill at their own pace. Photographs and videos will record how they move.
• Criteria: Able to walk at least 1 minute on a treadmill without stopping with or without holding onto side or front support rails; sufficient range of motion to perform the target acquisition tasks.
• Location: NIH, Bethesda, MD
• Contact: Jeffrey Fairman, (301) 451-1383, jeffrey.fairman@nih.gov or Thomas C Bulea, Ph.D., (301) 451-7533, buleatc@mail.nih.gov

5 years - 25 years

Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults

• Purpose:  This study is investigating new ways an NIH designed brace, called an exoskeleton, can be used in multiple settings while performing different walking or movement tasks, which we call ubiquitous use.
• Protocol:  Across all participants, three main exoskeleton control modes will be tested: assist, resist, and interleaved (alternating assist and resist). Control parameters will either be fixed for all tasks conducted or may adapt based on the motions of a given activity. Following informed consent and assent, screening, and calibration of control parameters, an acclimation period to the exoskeleton and control modes will occur. Each control mode will be tested across ubiquitous activities of daily living and outcomes will be compared to baseline (without wearing the exoskeleton).
• Criteria: Must be able to walk at least 10 feet with or without assistance; Knee joint range of motion of at least 25 degrees assessed with the hip extended in lying on back; and Ankle joint range of motion of at least 15 degrees with the foot in neutral alignment.
• Location:  NIH, Bethesda, MD
• Contact: Jesse H Matsubara, (301) 451-7530, jesse.matsubara@nih.govor Thomas C Bulea, Ph.D.,  (301) 451-7533, buleatc@mail.nih.gov

5 years – Up

Cerebral Palsy and the Study of Brain Activity During Motor Tasks

• Purpose: To study how the brain controls body movement in people with and without cerebral palsy which may lead researchers to develop new ways of training people with cerebral palsy to move better.
• Protocol:  People with and without CP would participate in one assessment session that lasts 2—3 hours during. This study has three parts. People with cerebral palsy will be selected for all three. Healthy volunteers will be asked to do only two of them. Everyone who participates will have EEG exams during movement. People with cerebral palsy may also have biofeedback sessions to train coordination of movement and brain activity. If it is their first time at NIH, we also need to send them to admissions and then do the informed consent and history and physical to confirm they are eligible. This may take another 1 -2 hours and can be done on the same or another day.   
• Criteria: Diagnosis of Bilateral CP, Able to walk at least 20 feet without stopping with or without a walking aid. Surgery free for six months in either the upper or lower extremities, and free from botulinum toxin injections within four months in either the upper or lower extremities. Able to follow simple directions.
• Location: NIH, Bethesda, MD
• Contact: Functional & Applied Biomechanics Section, 301-412-5989, ccrmdfab@mail.nih.gov, Diane L Damiano, Ph.D, 301-451-7544, damianod@cc.nih.gov 

8 years  – 21 years

Prospective Database Registry Study of Scoliosis in Children with Cerebral Palsy

• Purpose: To determine the radiographic and clinical outcomes of Scoliosis surgical and non-operative treatment in patients with Cerebral Palsy.
• Protocol: This observational study, either a family has chosen to proceed with a spinal fusion for scoliosis or they have refused the surgery or surgery is not recommended. Radiographic and health related quality of life outcomes will be measured after 2 and 5 years.
• Criteria: Diagnosis of CP, Scoliosis – see specifics
• Location: Rady Children’s Hospital, San Diego; A.I. DuPont, Wilmington, DE; Miami Children’s Hospital, Miami, FL; Johns Hopkins, Baltimore, MD; Boston Children’s, Boston, MA; Columbia University, NYC; New York University Hospital for Joint Diseases, NYC, Cincinnati Children’s Hospital, Cincinnati, OH; CHOP, Philadelphia, PA; Shriners, Philadelphia, PA; Texas Scottish Rite, Dallas, TX; Kluge Children’s Rehab, Charlottesville, VA; CHU Saint-Justine Hospital, Montreal, Canada; Hospital for Sick Children, Toronto, Canada; British Columbia Children’s Hospital, Vancouver, Canada
• Contact: Michelle C. Marks, PT, MA, 619-810-1430, mmarks@ssshsg.org

Up to 10 days old (Child)

Motor-voice Assessment in Infants (MAMI) (MAMI)

• Purpose: The purpose of this observational study is to discover features of normal and disordered motor-voice profiles that are biobehavioral markers of physical disability in infants.. The main questions it aims to answer are: (1) Identify voice factors among infants with newborn-detectable risk, (2) Identify association between individual characteristics (Gestational age at birth, global function, motor function) and voice factors; and (3) Examine unique features of voice production that are present in infacts with high risk for Cerebral Pasly.
• Protocol:  Participants will be asked to upload a 3-minute videos of their child at term-age, 3.5-, and 9-months of age. At the 3.5-month and 9-month time point parents can choose to attend an optional in-person assessment with their child.
• Criteria: gestational age of 24 0/7 - 41 6/7, admitted to the NICU, medically stable by 40 weeks of gestation (including off ventilator support) 
• Location:  Ohio State University, Columbus, OH
• Contact: Petra Sternberg, PhD, 614-572-5446, petra.sternberg@osumc.edu

0 to 18 years

A Multicenter Pediatric Deep Brain Stimulation Registry (DBS-R)

• Purpose: To develop a multicenter pediatric DBS registry that allows multiple sites to share clinical pediatric DBS data. The primary goals are to enable large-scale, well-powered analyses of the safety and efficacy of DBS in the pediatric population and to further explore and refine DBS as a therapeutic option for children with dystonia and other hyperkinetic movement disorders.
• Protocol:  To develop a multicenter pediatric DBS Database in order to define DBS as a therapeutic option for children with dystonia, other hyperkinetic movement disorders, or epilepsy. Collect Data to answer research questions such as: Which patients benfit from DBS? Which clinical variables contribute to the responsiveness of non-responsiveness to DBS? Which implant sites are preferred? What are the long-term effects of DBS in the pediatric population? How does DBS affect the quality of life in pediatric patients?
• Criteria: Individuals who have received or are about to receive DBS for any neurological movement disorder.
• Location:  Boston, MA
• Contact: Darius Ebrahimi-Fakhari, MD, PhD, 617-355-0097, movementdisorders@children.harvard

3 months - 2 years

Natural History of Cerebral Palsy Prospective Study

• Purpose: To describe the natural history of cerebral palsy (CP) as children develop over the first 2 years of life, in order to contribute to the existing knowledge of CP development. This information can assist clinicians and therapists with accurate information on prognosis and provide targeted interventions early and at the 'just-right' challenge. This study is intended to form part of a larger multi-site international study.
• Protocol: Infants will be assessed at regular intervals up to 24 months of age, across a variety of childhood development, to provide the first comprehensive developmental trajectories of this group. Where indicated, individual participants' results from this study will be used to inform their therapy.
• Criteria: High risk of CP and under the age of 12 months
• Location: Cincinnati Children’s Hospital, Cincinnati, OH
• Contact: Karen L Harpster, PhD, 513-803-3604, karen.harpster@cchmc.org,  Kelly Greve, PhD, 513- 636-3605, kelly.greve@cchmc.org

1 year and up

The PediQUEST Response to Pain Of Children With Neurologic Disability Pilot Randomized Controlled Trial (PQ-ResPOND)

• Purpose: To test the feasibility of running a full scale randomized controlled trial that compares the effect of the PQ-ResPOND intervention versus usual care to improve recurrent pain in children, adolescents, and young adults with severe neurologic impairment.
• Protocol: Participants' parents will answer surveys about their child's pain, symptoms, and use of complementary therapies, and about their own psychological distress and satisfaction with care. One group will receive the PQ-ResPOND intervention which consists of: activating parents and providers by using the PediQUEST system, a web platform that administers surveys and generates feedback reports alerting parents and providers about the child's experience, AND responding to child pain or discomfort by incorporating the Response team (members of the hospital's palliative care team) into the child's care to provide a standardized approach to managing recurrent pain. Researchers will use a comparison (control) group consisting of participants who will answer surveys and receive usual care (no feedback reports or consult with palliative care in this group) to see if a randomized design is feasible.
• Criteria: General criteria include parent child dyads who are current patients at Boston Children's Hospital and followed in the complex care program for severe neurologic impairment. See listing for additional criteria.
• Location: Boston Children's Hospital, Boston, MA - Additional Locations Pending
• Contact: Madeline E Avery, MPH, 617 643 8846, meavery@mgh.harvard.edu

2 years to 10 years

Feasibility and Reliability of the Melbourne Assessment-2 (MA-2) for Telehealth

• Purpose: The goals of this study are (1) Determine if a play based test of arm and hand movements is valid and reliable when conducted through telehealth for children with hemiplegic cerebral palsy. (2) Measure differences in parent, provider and child engagement when an assessment is conducted in-person compared to via telehealth. (3) Rate caregivers' overall impressions of procedures when an assessment is conducted in-person compared to telehealth.
• Protocol:  Participants will attend two visits, one in person and one through telehealth. During each visit, the child will play with common toys. The sessions will be video recorded and scored using two standardized assessments, the Melbourne Assessment-2 (MA-2) and the Assisting Hand Assessment.
• Criteria: Diagnosis of hemiplegic CP, hemiplegic cerebral palsy;able to attend an in-person visit in the research lab OR live within 60 miles of the research lab; able to attend a telehealth session with personal device
• Location:  Ohio State University, Columbus, OH
• Contact: Elizabeth Maus, DPT, 614-572-5446, elizabeth.maus@osumc.edu

3 years - 5 years

Speech Delay Study

• Purpose: To understand how speech movements of young children with speech delays or disorders differ from kids with typical speech development, in order to improve assessment and treatment of childhood speech disorders.
• Protocol: This study involves 1, 2 hour in-person visit with our research team. During the visit, children participate in standardized and informal speech and language testing while we record movements using small reflective stickers attached to the child’s face.  We also gather information. about medical history, therapy services and communication skills.
• Criteria: Children with speech delays or reduced intelligibility secondary to cerebral palsy. Live in, near or can travel to Boston.
• Location: Northeastern University, Boston, MA
• Contact: Dr. Kristen Allison at smilespeechlab@northeastern.edu or call 617-373-3697. 

3 years to 8 years

A Novel Program Using Ride-on Toys to Improve Upper Extremity Function in Children With Hemiplegia

• Purpose: To assess the feasibility and utility of 2 types of play-based training programs co-delivered by researchers and caregivers within home/community settings to promote arm function among 3-to-8-year-old children with hemiplegia.
• Protocol: Two investigators will assess the feasibility of implementation and acceptance/satisfaction associated with a researcher-caregiver co-delivered community-based training program involving either joystick-operated powered ride-on toys (SPEED training) or creative upper extremity training (CRAFT training).The investigators will also compare the effects of these 2 types of training programs on children's arm motor function and spontaneous use of their affected arm during daily activities.
• Criteria: Diagnosis of hemiplegia or clear asymmetry in upper extremity strength and control and can maintain sitting for at least 15 minutes.
• Location: University of Connecticut, Storrs, CT
• Contact: Sudha M Srinivasan, PhD, 860-486-6192, sudha.srinivasan@uconn.edu

3 years – 9 years

Aquatic Therapy for Children with Neuromotor Deficits

• Purpose: To explore the feasibility, fidelity and acceptability of an aquatic therapy assessment and intervention for children with neuromotor deficits.
• Protocol: The study includes an intake evaluation session, twenty sessions of aquatic therapy (twice a week for 10 weeks) targeting  target swim safety skills, upper extremity function and self care participation and performance and a post evaluation session. This takes place in Columbus, Ohio.
• Criteria: Diagnosis of CP; Child with neuro-motor diagnosis (CP, hypoxia, etc.)
• Location: Columbus, Ohio State, OH
• Contact: Erika Kemp,  614-292-8167, erika.kemp@osumc.edu    

3 years to 17 years

Whole Body Vibration and Serial Casting for Children with CP 

• Purpose: To study is serial casting in combination with Whole Body Vibration results in more rapid clinical change, therefore reducing the need for prolonged intervention.
• Protocol: This is a randomized trial comparing serial casting only; serial casting plus exercise; and serial casting, exercise and whole body vibration on ankle range of motion.
• Criteria: GMFCS I-III; can stand with upper extremity support or less.
• Location: Nationwide Children's Hospital, Columbus, OH
• Contact: Ben Reader, DPT, Ben Reader, DPT, 614-722-8374, ben.reader@nationwidechildrens.org
   

4 years - 6 years

Stand-on Ride-on Power Mobility Devices for Children With Cerebral Palsy

• Purpose: To learn about the biomechanical factors underlying the beneficial changes in children with cerebral palsy after using individually-adapted stand-on ride-on power mobility devices (PMD). Specific aims are to learn: How does the use of stand-on PMDs affect static balance in children with cerebral palsy?and How does the use of stand-on PMDs affect dynamic balance and mobility function in children with cerebral palsy?
• Protocol: Children will use individually-adapted stand-on PMDs for three months. During this time they will undergo tests to measure static balance, dynamic balance, and mobility function before and after the intervention. Participants will receive a full biomechanical assessment (kinematics, kinetics, muscle activity, gait spatiotemporal characteristics). Researchers will compare pre-intervention and post-intervention measurements to quantify improvements in balance, muscle activation, and mobility. All participants will get to keep their customized car.
• Criteria: Spastic Diplegia, GMFCS II - III
• Location: University of North Florida, Jacksonville, FL
• Contact: Guilherme M Cesar, PhD, PT, 904-620-2664, g.cesar@unf.edu 

4 years - 17 years

Cerebral Palsy Upper Extremity Orthotic Device

• Purpose: To assess the effectiveness of an upper extremity orthotic device in improving the upper extremity function of children with cerebral palsy who have limited use of their hands.
• Protocol: Investigators will compare experimental 3D printed orthotic device plus occupational therapy to occupational therapy alone without the device.
• Criteria: Moderate-severe hand disability as graded by the Manual Ability Classification System, active movement of the elbow, ability to participate in goal-making and repetitive tasks.
• Location:  Rutgers NJMS, Newark, NJ and Children's Specialty, Union, NJ
• Contact: Alice Chu, MD, 973 972 2076, chual@njms.rutgers.edu

5 years – 17 years

Grand Valley State University (GVSU) Skills on Wheels

• Purpose: To address gaps in Manual Wheelchair training for children and provide pilot data for a future large-scale, multi-site research project involving a randomized controlled trial. Aim 1 is to explore the influence of Skills on Wheels on children's manual wheelchair skills and confidence in their manual wheelchair use. Aim 2 is to investigate the influence of Skills on Wheels on children's psychosocial skills, social participation, and adaptive behavior.
• Protocol: 6-week manual wheelchair skills training program.
• Criteria: Reside in Michigan, difficulty walking and use a manual wheelchair at least 25% of the time, able to follow simple instructions.
• Location: Grand Valley State University, Grand Valley, MI
• Contact: Lisa Kenyon, PhD, 616-331-5653, kenyonli@gvsu.edu  

5 years - 17 years

Non-Invasive Measurement of Pulmonary Dysfunction in Children with Cerebral Palsy

• Purpose: To study breathing in children with CP using the pneuRIP device. The pneuRIP device is an investigational device (not approved by the FDA) that uses bands across the chest and abdomen to measure how well your child is breathing.
• Protocol: This protocol addresses pulmonary dysfunction in severe cerebral palsy by using a novel non-invasive respiratory sensor. The two aims of the project are to 1) provide a screening tool to detect respiratory distress and 2) Find a correlation between the degree of pulmonary dysfunction and scoliosis in children with cerebral palsy.
• Criteria: Diagnosed with CP, GMFCS levels IV and V.
• Location: Nemours Children’s Hospital, Delaware Valley
• Contact: Alice Taylor, alice.taylor@nemours.org or 302 651 4394

5 years - 17 years

Em-power: Maximizing Functional Independence for Children With Severe Cerebral Palsy

• Purpose: For children with severe cerebral palsy, a powered wheelchair (PWC) may provide their only option for functional mobility and independence. PWC use is often restricted to a small percentage of children who can quickly demonstrate proficient PWC skills within a single 30-minute PWC trial. We think an 8-week PWC skills training intervention will produce greater improvements in children's PWC skills capacity immediately after the intervention and at an 8-week follow-up assessment.
• Protocol: This 2-arm, parallel group, single blinded, pre-test-post-test randomized controlled trial will test our hypothesis that an 8-week PWC skills training intervention will produce greater improvements in children's PWC skills capacity immediately after the intervention and at an 8-week follow-up assessment.
• Criteria: (1) Diagnosis of severe CP (Gross Motor Function Classification System Level IV or V); (2) Inability to functionally walk or functionally propel a manual wheelchair as assessed by the Principal Investigator a licensed physical therapist; and (3) Demonstrate cause and effect skills
• Location: Grand Valley State University, Grand Rapids, MI
• Contact: Lisa K. Kenyon, PT, PhD, PCS, 616-331-5653, kenyonli@gvsu.edu 

6 years – 17 years

Robotic Trust-Postural Intervention for Children with Cerebral Palsy

• Purpose: To test the efficacy of a motor learning-based postural and reaching control intervention delivered with the robotic Trunk-Support-Trainer (TruST) compared to the same motor learning-based intervention delivered with Static Trunk Support Equipment in children with cerebral palsy (CP) classified as III and IV with the Gross Motor Function Classification System (GMFCS).
• Protocol: This is a randomized trial with two groups. One group will use the Robotic Trunk Trainier while the other group uses the Static Trunk Support equipment. The experimental and control groups will both receive effective postural-reaching training based on motor learning and control principles. In both groups, participants will engage in play and functional activities that elicit arm movement and challenge trunk postural control, and the motor tasks and activities will be progressed. Both groups receive twelve 2hr training sessions (3 times per week for 4 weeks) with assessments before, after and 3 months following intervention.
• Criteria: Diagnosis of Bilateral CP - Diplegia, Tetraplegia and Quadriplegia; GMFCS III-IV; Ability to sit 5s with trunk support between mid-ribs and pelvis; Ability to follow basic verbal instructions. 
• Location: Columbia University, NYC
• Contact: Karen Chin 212-678-3332, cpresearch@tc.columbia.edu

6 years -17 years

tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy

• Purpose: To test the efficacy of transcranial direct current stimulation combined with bimanual training on hand function in children with unilateral spastic cerebral palsy (USCP). tDCS is a non-invasive form of brain stimulation which is believed to enhance the effects of motor training on hand function. It is a safe technique that has been use with over 200 children.
• Protocol: Children who enroll in the protocol will be randomized to receive either sham (not stimulating) tDCS plus bimanual training, or active (stimulating) tDCS plus bimanual training. There will be 5 training sessions (2 hours/session): 2 hours of bimanual training a day for 5 consecutive days. Transcranial Direct Current Stimulation will be applied during the first 20 minutes.
• Criteria: Diagnosis of Hemiplegia, Ability to lift and grasp with affected hand
• Location: White Plains, NY
• Contact: Kathleen Friel, PhD, 914-368-3116, kaf3001@med.cornell.edu

8 years - 17 years

Speech Modification Study

• Purpose: To better understand why and how speech modification strategies can lead to improved intelligibility and communication in children and adolescents with dysarthria secondary to CP by (1) Comparing the effectiveness of 3 speech modification strategies and (2) Identifying acoustic and kinematic markers that predict which strategies will be optimal for individual children and adolescents.
• Protocol: This study involves 1 or 2 in-person sessions with our research team. During the first session, children participate in standardized and informal speech and language testing and we gather information about medical history, therapy services and communication skills. In the second session, children are asked to repeat sentences using the three speech modification strategies while we record movements using small reflective stickers attached to the child’s face.
• Criteria: Children with Dysarthria secondary to cerebral palsy. Live in, near or can travel to Boston.
• Location: Northeastern University, Boston, MA
• Contact: Dr. Kristen Allison at smilespeechlab@northeastern.edu or call 617-373-3697

8 years – 24 years

Sensorimotor Control During Postural Transitions in CP

• Purpose: To investigate whether a light electrical stimulation to leg muscles and joints can help people with Cerebral Palsy (CP) maintain balance during everyday tasks such as getting up from a chair and walking.
• Protocol: Cross sectional study in children with CP and age matched with typical developing children. Each group will undergo two stimulation conditions, stochastic resonance (SR) stimulation and a no stochastic resonance (noSR) condition while performing postural transitions. Participation is 1-day with pre-and post testing on the same day. 
• Criteria: Ambulatory CP, GMFCS I-II.  Able to stand up from a chair and start walking;  Seizure-free or well-controlled seizures; No other neurological or musculoskeletal disorders (e.g. dystonia, severe scoliosis, hip instability; Able to communicate pain or discomfort.
• Location: University of Delaware, Newark, DE
• Contact: Samuel CK Lee, PT, PhD, 302-831-2450,  slee@gmail.com 

8 years to 99 years

High Intensity Exercise and Improving Physical Activity Among People With Neurologic Dysfunction

• Purpose: The purpose of this study is to evaluate whether participation in an 8-week, twice-a-week high-intensity exercise program for people with neurologic disability run by Doctor of Physical Therapy students increases physical activity in the everyday life.
• Protocol:  Participants will receive two times a week for 8 weeks one hour of individualized exercise program that is based on clinical practice guidelines for high intensity exercise.
• Criteria: Physical disability that limits mobility and activities of daily living, and a neurodevelopmental disability OR neurological disability; can understand/speak English
• Location:  University of Hartford, West Hartford, CT
• Contact: Mary E Gannotti, PT, PhD, 860-768-5373, gannotti@hartford.edu

8 years to 17 years

Robotic Knee Orthosis-assisted Walking in CP

• Purpose: This study aims to assess the effectiveness of Agilik, a Robotic Knee Orthosis, as an assistive device for children with CP and crouch gait.
• Protocol: Ten children with CP will be recruited for this pilot study. Each child will participate in a total of four visits over four weeks duration. The first three visits will also include Robotic Knee Orthosis (RKO) device fitting and tuning, followed by RKO-assisted walking practice to help with device acclamation. The walking practice will last up to 30 minutes. A two-minute walk test (2MWT) will be conducted at the first visit, which will serve as a reference to assess any shift in endurance from device-tuning/practice visits. The fourth and final visit will include 2MWT and 3D motion capture of shod and RKO-assisted conditions and may take up to 3 to 4 hours.
• Criteria: Cerebral Palsy, GMFCS II, Crouch Gait
• Location: Hospital for Special Surgery (HSS), NYNY
• Contact: David M Scher, MD, 212 606-1253, scherd@hss.edu

8 years to 17 years

Speech and Arm Combined Exergame (SPACE)

• Purpose: The purpose of this study is to develop innovative home therapy games to train the weak arm and improve speech intelligibility (clarity) of children with hemiplegia from cerebral palsy. The investigators are exploring the effects of these therapy games and how they change the children's speech, hand movement, and brain activation.
• Protocol: Participants will engage in daily 30 minutes sessions of therapy video games 5 days per week for 8 weeks and attend 4, 2 hour in person assessments during that time. 
• Criteria: Cerebral Palsy, GMFCS I-IV, Speech Impairment
• Location: Rutgers University, Newark, NJ
• Contact: Young Hwa M Chang, PhD, CCC-SLP, 617-959-4597, ym.chang@rutgers.edu

12 years – up

Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions

• Purpose: To assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions to improve their wellness and self-management skills compared to those who receive standard of care only.
• Protocol: Participants randomized into this group will use the mHealth system, a suite of apps to support participants manage their self-care and the clinician portal. Participants will use the system for 1 year in conjunction with standard care. Participants in the control group will receive standard care. 
• Criteria: Able use a smartphone or tablet and can pass screening. See specifics
• Location: University of Pittsburgh, Pittsburg, PA
• Contact: Zara Ambadar, Ph.D, 412-608-6118, ambadarz@upmc.edu 

16 years - up

Radiosurgery Treatment for Spasticity Associated with Stroke, SCI & CP (SPASM)

• Purpose: To test if Stereotactic Radiosurgery Dorsal Rhizotomy is a safe and effective treatment for spasticity. 
• Protocol: Researchers are comparing two groups, treatment group to “sham” treatment group. Patients in the treatment group will receive the SRS Dorsal Root Rhizotomy while the “sham” group will receive simulated treatment. Spacticity reduction and side-effects will be monitored for up to 2 years post treatment. After 6-months, sham group may cross over to the treatment group.
• Criteria: Chronic spasticity 
• Location: Ohio State University Wexner Medical Center, Columbus, OH
• Contact: Destiny West, 614-366-7822, Destiny.West@osumc.edu

10 weeks - 20 weeks

Families Filming Infants Learning to Move

• Purpose:  To improve accuracy in the early detection of neurodevelopmental impairment, especially CP, by evaluating the timepoint (in weeks post term age) that the Prechtl GMA is most useful for prediction of neurodevelopmental impairment at two years of age in children with and without medical complexity. 
• Protocol: See study protocol. Observation of movement patterns through video recordings and neurodevelopmental battery of assessments.
• Criteria: Infants 10 weeks to 20 weeks
• Location: Northwestern University, Chicago, IL
• Contact: Ryan Millman, B.S., 847-530-2319, ryan.millman@northwestern.edu

3 months - 2 years, 11 months

Implementation of Therapy Together

• Purpose: To learn about the implementation of Therapy Together, a pediatric constraint-induced movement therapy program in young children with unilateral cerebral palsy. The study aims to answer: (1) Is the Therapy Together program effective in improving hand function and occupational performance compared to usual care? (2) Is it feasible to implement the Therapy Together program within the standard care, early intervention framework?
• Protocol: Participants will participate in an 8-week pediatric constraint-induced movement therapy program. Researchers will compare the group completing the Therapy Together Program to a group that is receiving usual care to see if there is a difference in the change in hand function, occupational performance, and development.
• Criteria: Babies at-risk for developing cerebral palsy or have been diagnosed with cerebral palsy who present with: asymmetric hand use; unilateral upper limb impairment; who visually attend to and demonstrate interest in objects and who attempt to reach for or grasp objects with impaired upper extremity. 
• Location: Scottish Rite Hospital For Children, Frisco, TX
• Contact: Angela Shierk, PhD, 469-412-7172 ext 1045, angela.shierk@tsrh.orgor Heather Roberts, PhD, 214-794-8117, hroberts3@twu.edu

2 years to 10 years

Examining the Effect of Eye Gaze Technology on Children With Cortical Visual Impairment

• Purpose: The goal of this study is to learn about eye gaze technology's use as an assessment and intervention of visual skills and the impact on occupational performance in children with cortical/cerebral visual impairment.
• Protocol:  Participants will complete the Pre-test with Canadian Occupational Performance Measurement, Cortical Visual Impairment Range, Sensory Profile and Sensory Processing Checklist for Children with Visual Impairment. Then will participate in eye gaze technology activities using eye gaze software with graded visual games for 20 minutes per day for 4 weeks. Observations of positioning, head/eye position, sensory processing, and types of eye gaze activities used during the session. Pre test, daily and post test percentage scores on the eye gaze activities will be recorded. Then the child will complete post testing with the Canadian Occupational Performance Measurement and Cortical Visual Impairment Range.
• Criteria: Diagnosis of Cortical Visual Impairment
• Location:  Kansas City, Missouri
• Contact: Tammy Bruegger, OTD, 816-501-4342, Tammy.Bruegger@rockhurst.edu

2 years - 12 years

Activities-based Locomotor Training Program Versus Traditional Physical Therapy in Children With Cerebral Palsy

• Purpose:  To investigate the impact of an intensive activities-based locomotor training program as compared to traditional physical therapy on activity, participation, and central and peripheral neurophysiological adaptation in children with cerebral palsy.
• Protocol:  Observational research will be performed to assess the change in outcome measure scores over time among participants after the AB-LT intervention. Outcome measures will be obtained 4 times, occurring every 3 weeks over a period of 9 weeks: pre-intervention, post-intervention, pre-traditional therapy, and post-traditional therapy. A washout period of 3 weeks will occur between the AB-LT intervention and traditional therapy.
• Criteria: Diagnosis of CP, Enrolled in a 3-week AB-LT program and/or participate in traditional physical therapy.
• Location: Baylor University, Waco, TX
• Contact: Megan Flores, 512-529-4421, megan_flores@baylor.edu

3 years - 5 years

School Readiness in Preschool Aged Children with CP
 

• Purpose:  To learn about the feasibility, acceptability, and impact of a school readiness program for preschool-aged children with unilateral cerebral palsy. The main question[s] it aims to answer are: (1)Is it feasible to implement an intensive school readiness program for preschool-aged children with UCP? (2) Is the program acceptable to the children and their caregivers? and (3) What is the impact of the program on school readiness?Protocol:  The School Readiness Program is an 8-week intensive therapy program focused on school readiness skills for young children with unilateral cerebral palsy (UCP). The program will include 64 hours of intervention supporting development and goal attainment across 5 school readiness domains: (1) health and physical development, (2) emotional well-being and social competence, (3) approaches to learning, (4) communication skills, and (5) cognitive skills and general knowledge.
• Criteria: Unilateral/hemiplegic CP
• Location: Frisco, TX, Scottish Rite for Children
• Contact: Angela Shierk, PhD, (469) 412-7172 ext 1045,  angela.shierk@tsrh.org

3 years – 17 years 

Acceptability and Efficacy of GO MOVE

• Purpose: To learn about the acceptability and efficacy of Go Move, a mobile website developed to assist youth with unilateral cerebral palsy and their caregivers with setting goals and selecting exercises and activities to meet the goals
• Protocol: Participants will set up and participate in a goal-driven home program using the Go Move mobile website. Participants will spend 1 hour and 15 minutes per week for 6 weeks working on their home program and will complete pre-intervention and post-intervention assessments.
• Criteria: Unilateral CP, GMFCS levels 1 or 2. MACS levels 1-3. Age 3-17 years old, ability to follow directions, ability to complete the assessment protocol, and the ability to access the GO MOVE webpage on a personal device
• Location: Scottish Rite Hospital For Children, Frisco, TX
• Contact: Angela Shierk, PhD, 469-412-7172 ext 1045, angela.shierk@tsrh.orgor, Heather Roberts, PhD, 214-794-8117, hroberts3@twu.edu

3 years – 18 years

Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy

• Purpose: To characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy.
• Protocol: Patients will receive 2 post-operative MRI's with DTI and rsfcMRI at 2 months and 12 months.
• Criteria: Diagnosis of Spastic Diplegic CP and Selective Dorsal Rhizotomy
• Location: UT Health/Hermann Memorial Hospital, Houston, TX
• Contact: Manish N Shah, MD, 713 500-7410, Manish.N.Shah@uth.tmc.edu ,Bangning L Yu, RN, PhD, 713 500-7363, Bangning.Yu@uth.tmc.edu

3 years - 18 years

The Impact of Commercial Blenderized Formula on Caloric Needs, Gastrointestinal Symptoms, and Gut Microbiome in Children With Cerebral Palsy (CP)

• Purpose:  To compare the Pediatric Quality of Life Inventory Gastrointestinal Symptoms Scale Gastrointestinal Symptoms Scale (GI-PedsQL) differences , to assess the differences in stool microbiome and stool metabolomics , to assess differences in salivary cytokine profile , to assess differences in weight change , to compare the use of antacid medications and to compare the use of laxative medications in patients on commercial formulas (CF) versus commercial blenderized tube feed (CBTF).
• Protocol: During the experimental phase/CBTF phase of the trial the participant will be assessed by a dietician and be fed the commercial blenderized formula to meet their caloric needs. During the active comparator (CF) phase of the trial, the participant will be fed the commercial formula to meet their caloric needs per standard of care.
• Criteria: Individuals with CP receiving >75% of total daily caloric requirements from commercial formulas (CF) via a gastrostomy tube 12french or greater;  insurance covers a CBTF
• Location: University of Texas Health Science Center, Houston, TX
• Contact: Fernando Navarro, MD, (713) 500-5663,  Fernando.Navarro@uth.tmc.edu or Ana F Alvarez, (713) 500-5663, Ana.B.FadhelAlvarez@uth.tmc.edu

4 years – 12 years

Neuromuscular Mechanisms of Specific Trunk Interventions in Children with CP

• Purpose: To determine the effect of repeated pelvis perturbation training on trunk posture and locomotor function in children with CP.
• Protocol: Participants will be randomly assigned to two groups. In the Robotic Hippotherapy group, each participant will be trained on a robotic horse for 40 minutes. In the Conventional Physical Therapy Group, each participant will be trained for 40 minutes, which will include 10 minutes of stretching, followed by 10 minutes of sitting and 10 minutes of standing balance training, and 10 minutes of treadmill walking.
• Criteria: Diagnosis of Bilateral Spastic CP, ALL GMFCS LEVELS; Able to remain seated without help for ≥10s.; Able to signal pain, fear or discomfort reliably; Children with mild scoliosis; Children with CP who have no prior hippotherapy experiences within 6 months.
• Location: Shirley Ryan Ability Lab, Chicago, IL
• Contact: Ming Wu, 312-238-0700, w-ming@northwestern.edu

4 years - 17 years

Dance Program for Youth with Cerebral Palsy

• Purpose: The goal of this prospective cohort study is to learn about the impact of an adapted dance program in youth with cerebral palsy.
• Protocol: A quasi-experimental mixed-method study will be conducted with clinical assessments completed pre-intervention and post-intervention to determine the feasibility and the impact of the intervention. The intervention will consist of participating in a 1-hour class, two times a week for 10 weeks.
• Criteria:  Ambulatory and able to use hands with some limitations.
• Location: Frisco, TX, Scottish Rite for Children
• Contact: Angela Shierk, PhD, (469) 412-7172 ext 1045,  angela.shierk@tsrh.org

5 years - 17 years

Chronic Post Surgical Pain in CP

• Purpose: The study purpose is to document the typical trajectory of perioperative pain experience in Cerebral Palsy (CP) and to identify important predictive factors for the development of chronic postsurgical pain.
• Protocol: Participants will be asked to fill out questionnaires/surveys via email and text message; participants receive in-person sensory tests; participants receive in-person Gait and Motion Analysis
• Criteria: CP diagnosis, Have a scheduled lower extremity or spine orthopedic surgery.
• Location: Gillette Children’s, St. Paul, MN
• Contact: Maykala Owens, 651-229-1717, maykalajowens@gillettechildrens.com

5 years – 17 years

Cerebral Palsy Motor Promotion with Transcranial Direct Current Stimulation 

• Purpose: To test if transcranial direct current stimulation (tDCS) can be applied to boost the efficacy of constraint-induced movement therapy (CIMT) in children with HCP and examine brain mechanisms related to individual outcomes.
• Protocol: This study will test how tDCS influences the efficacy of CIMT in children with HCP by comparing motor performances between two groups. The first group of children with HCP will receive anodal tDCS and CIMT while the second group of children with HCP will receive sham tDCS and CIMT during the intervention phase.
• Criteria: Hemiplegic CP
• Location: Dallas, TX, Childrens Health Medical Center
• Contact: Yanlong Song, PhD, 214-648-0593, yanlong.song@utsouthwestern.edu

5 years – 18 years

Effectiveness of Robotic Gait Training and Physical Therapy for Children and Youth with Cerebral Palsy

• Purpose: To compare: 1) a walking training program with the Lokomat® robotic device (LOK), 2) a functional physical therapy program (fPT) that includes activities to enhance balance/co-ordination/endurance and advanced motor skills conducted over 'real ground', 3) a combined Lokomat® + functional physical therapy (LOK+fPT) program, and 4) a regular maintenance therapy condition (CONT) for ambulatory children and youth with CP.
• Protocol:  The three intervention programs will consist of sixteen 50-minute sessions given twice weekly over 8 to 10 weeks.
• Criteria: Ambulatory CP, GMFCS II or III
• Location: Shirley Ryan Ability Lab, Chicago, IL; University of Alberta, Alberta, Canada; Holland Bloorview, Toronto, Canada
• Contact: Lesley Wiart, PhD, 780-492-2971, lwiart@ualberta.ca   

7 years - 18 years

Gait Adaptation and Biofeedback for Cerebral Palsy

• Purpose: To understand how children with CP adapt and learn new ways of moving by evaluating walking function in children with cerebral palsy (CP). This research will help develop better treatments to enhance walking capacity and performance for children with CP.
• Protocol: 12 sessions (20 minutes of walking on a treadmill) over a 6-8 week period while receiving audiovisual biofeedback based on the muscle activity of their ankle plantarflexors. 12 sessions (20 minutes of walking on a treadmill) over a 6-8 week period while receiving sensorimotor biofeedback with an ankle exoskeleton that provides resistance to ankle plantarflexion during the stance phase of gait. 12 sessions (20 minutes of walking on a treadmill) over a 6-8 week period while receiving both audiovisual and sensorimotor biofeedback.
• Criteria: Diagnosis of bilateral cerebral palsy, GMFCS II, able to walk on treadmill for 20 minutes; No lower extremity injury or surgery in prior 12 months; No prior selective dorsal rhizotomy surgery
• Location: Gillette Children’s, St. Paul, MN
• Contact: Katherine M Steele, PhD, 206-685-2390, kmsteele@uw.edu

7 years to 18 years

Robot-assisted Training in Children With CP

• Purpose: To test whether robot-assisted hand training with Amadeo improves manual functions and induces cerebral neural plasticity in children with CP.
• Protocol: Investigators will measure manual motor and sensory functions with behavioral tasks and assess neural activities in the sensorimotor cortical network with high-density electroencephalography (HD-EEG) and transcranial magnetic stimulation (TMS) one day before, one day after, and two months after the robot-assisted training.
• Criteria: GMFCS I or II CP
• Location:  Cook Childrens Hospital, Ft. Worth
• Contact: Laurie J Bailey, PhD, 682-885-2488, laurie.bailey@cookchildrens.org

7 years to 18 years - Not yet recruiting

Evaluating the Effects of an Electrical Stimulator on Improving the Walking Ability of Children With Cerebral Palsy (CP)

• Purpose: The goal of this study is to see if gentle electrical stimulation can help children with cerebral palsy (CP) walk more easily. This stimulation, called neuromuscular electrical stimulation (NMES), sends small pulses to the muscles to help them activate. Researchers will test different ways of using NMES to find out which method works best.
• Protocol:  The study consists of two assessment sessions. During all sessions, the participants will walk on a treadmill with and without NMES assistance at self selected walking speed. The assessment sessions consist of multiple NMES conditions. Each condition lasts about 1 minute and will be repeated 3 times, with 30 seconds rest between trials for each condition and 5 minutes between each condition. The total walking time will not exceed 30 minutes. Each visit will last about 3 hours. The study will compare different stimulation settings to see which one helps the most.
• Criteria: Cerebral Palsy, GMFCS I-III
• Location: University of Nebraska, Omaha, NE
• Contact: Ahad Behboodi, PhD, 402-554-7525, abehboodi@unomaha.edu

8 years -12 years 

Brain-Computer Interface (BCI) for AAC

• Purpose: Researchers at the University of Nebraska are exploring new ways to help children 8-12 years old with physical challenges communicate using brain-controlled devices. These devices let kids control a computer with just their brain waves, no physical movement is needed. We want to understand how kids learn to use these devices, what they like, and what helps them succeed.
• Protocol: We'll use a special cap with sensors (like a swim cap) to read brain signals. The computer will show different pictures, and kids will focus on the one they want to select.
• Study Details: The study takes place over three sessions at the University of Nebraska-Lincoln. Each session will last 60–90 minutes. Two sessions will focus on using the brain-controlled computer, and one will involve using an iPad app. We'll also check things like fatigue and attention during these sessions. Participants will receive $180 per session (total $540). Mileage reimbursement may be available. To see a video on what helping us is like, go here!
• Criteria: Children aged 8–12 with a diagnosis of cerebral palsy, who have no electrical implants (e.g., pacemakers or pumps), no history of seizures, are not colorblind, and have English as their first language.
• Location: University of Nebraska-Lincoln, Lincoln, Nebraska
• Contact: Dr Kevin Pitt: 402-472-3846, Kevin.Pitt@unl.edu

8 years -17 years

Quantifying Energetic Demands of Walking for People With Cerebral Palsy

• Purpose: The purpose of this study is to examine the underlying mechanisms that contribute to high energy costs for people with cerebral palsy (CP) as they walk.
• Protocol: Participants will complete a standard gait and motion analysis at varying levels of harness support and stabilization (low, moderate, and high levels).
• Criteria: Bilateral cerebral palsy, GMFCS II; No surgery within the last 9 months;  No current baclofen pump; Prior gait and motion analysis at Gillette Children's Specialty Healthcare
• Location: Gillette Children’s, St. Paul, MN
• Contact: Michael Schwartz, PhD, 651-229-1745, mschwartz@gillettechildrens.com

8 years – 18 years

Augmenting Ankle Plantarflexor Function in Cerebral Palsy

• Purpose: To quantify improvement in ankle muscle function and functional mobility following targeted ankle resistance gait training in ambulatory children with cerebral palsy and to determine the efficacy of adaptive ankle assistance to improve capacity and performance during sustained, high-intensity, and challenging tasks in ambulatory children with CP.
• Protocol: This randomized controlled trial will compare functional outcomes following targeted ankle resistance training (2 visits/week for 12 weeks) vs. dose-matched standard physical therapy (RM) and vs. dose-matched standard treadmill training. Task capacity and performance will be measured by duration, metabolic cost, speed, and stride length, as applicable.
• Criteria: Ambulatory CP; GMFCS I-III
• Location: Gillette Children’s, St. Paul, MN
• Contact: Zach Lerner, PhD, 928-523-1787,  zachary.lerner@nau.edu, Ray Browning, PhD,  ray@BiOMOTUM.com  

11 years to 45 years - Not Yet Recruiting

Improving Activity in Individuals with Cerebral Palsy (Fitbit)

• Purpose: This study will use wearable physical activity monitors to assess if behavioral coaching is a viable strategy for combating the reduced physical activity seen in the CP population.
• Protocol:  The participants with CP will initially undergo neuroimaging and a battery of clinical assessments. After completing the baseline tests, the participants will undergo 8-weeks of behavioral coaching where they are encouraged to increase the number of steps they take per-day. After completing the 8 weeks, the participants will repeat the same assessments that were performed at baseline.
• Criteria: Ambulatory Cerebral Palsy, GMFCS I-III
• Location: Boys Town National Research Hospital, Boys Town, NE
• Contact: Max J Kurz, PhD, 531-355-8924,  max.kurz@boystown.org 

11 years to 45 years  

Neuromodulation of the Cortex and Spinal Cord

• Purpose: To begin to fill the knowledge gap of robust evaluation of these neuromodulation techniques on the neurophysiology of those with CP by looking at (1) the difference in the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence of persons with CP and (2)  the effect of transcutaneous current stimulation applied over the cortex and/or spinal cord on the sensorimotor cortical activity, spinal cord dynamics, and corticospinal coherence. 
• Protocol:  Participants will undergo baseline sham or stim intervention/brain imaging/clinical assessments, and then repeat with opposite intervention.
• Criteria: GMFCS levels I-IV
• Location:  BoysTown, Nebraska
• Contact: Ben Max J Kurz, PhD, 531-355-8916, max.kurz@boystown.org

14 years – 30 years

Robotic Exoskeleton Gait Training in Adolescents with Cerebral Palsy

• Purpose: To take a fresh new approach on how robotic exoskeletons can be used in a therapeutic setting. As opposed to using them as a compensation tool, we are proposing to use them to perturb the legs to drive beneficial neuroplasticity in the key brain areas that govern the leg motor actions.
• Protocol:  Participants will undergo baseline mobility/brain imaging/cognitive testing. After completing the baseline tests, the participants with CP will undergo the therapeutic gait training using either traditional physical therapy or utilizing a robotic exoskeleton consisting of 24, 60 minute treatment sessions that will be performed 3 times-a-week for an 8-week period. After completing all of the therapeutic gait training sessions, the participants will repeat the same assessments that were completed at baseline. The two groups will be compared based on the assessments for therapeutic outcomes.
• Criteria: Diagnosis of CP
• Location: Boys Town National Research Hospital, Boys Town, NE
• Contact: Max J Kurz, PhD, 531-355-8916, max.kurz@boystown.org 

18 years - 89 years

Nomad P-KAFO Study

• Purpose: To evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk. 
• Protocol: Participants wear a sensor that records everyday activities and mobility. Perform measures of mobility and different activities of participation using their own brace. Perform measures of mobility and different activities of participation using the Nomad powered KAFO
• Criteria: Regular use of a unilateral or bilateral KAFO or SCO or other passive KAFOs for impairment due to neurological or neuromuscular disease, orthopedic disease, or trauma. Willing to wear and charge an activity monitor for three-months home trials.
• Location: Shirley Ryan Ability Lab, Chicago, IL
• Contact: Arun Jayaraman, PhD, 312-238-6875, ajayaraman@sralab.org