Clinical Trials by Geographic Location

Updated June 6, 2022
Clinical Trials Highlighted By Region - Updated June 2022

The Cerebral Palsy Foundation is committed to sharing the most up to date Cerebral Palsy clinical trial and research study information with you on an ongoing basis. 

Every month we'll highlight new or innovative clinical trials around the United States that may be a fit for you or your family member.  Check back often for what's new and exciting in the world of cerebral palsy research.

Currently, there are 71 clinical trails actively recruiting participants around the United States in different geographic locations. We have highlighted a few below. You can click on each link to learn more about the trial or study, including where it is located and what medical or research institution is involved.  We've included research studies and trials focusing on both children and adults with different types of cerebral palsy.

IMPORTANT: * is a resource provided by the U.S. National Library of Medicine. Listing a study on does not mean it has been evaluated by the Cerebral Palsy Foundation and does not constitute medical advice.  Before participating in a study, talk to your health care provider and learn about the risks and potential benefits.

Multi-Center and NIH Based Clinical Studies
Map of the United States colored blue to indicate multistate or NIH based studies

1) Dopamine and Motor Learning in Cerebral Palsy

Study Description

Cerebral palsy (CP) is the most common lifelong motor disability. Dopamine (DA) is a neurotransmitter that plays a role in cognition, emotions, and behavior. DA may also play a role in motor skill learning. Genes associated with DA function may impair an individual's ability to learn new cognitive or motor skills. Some children with CP learn motor skills quickly, while others struggle. Researchers at the National Institutes of Health want to know if DA gene variations are to blame for some of this variation.

2) Cerebral Palsy Hip Outcomes Project - International Multi-Center Study

Study Description

The primary goal of this project is to assess the efficacy of various intervention strategies in preventing or alleviating symptoms associated with hip instability in children with severe cerebral palsy, with the validated Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD) questionnaire serving as the primary outcome measure of health-related quality of life for this population.

3) Perinatal Arterial Stroke: A Multi-Site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)

Study Description

The proposed study is a Phase III trial designed to assess the efficacy of two different doses of I-ACQUIRE for children 8 to 36 months with PAS and hemiparesis. 240 children will be randomly assigned to one of 3 treatment groups (N=80 per group). 1) Moderate Dose I-ACQUIRE (3 hrs/day, 5 day/wk X 4 wks), 2) High Dose I-ACQUIRE (6hrs/day, 5 days/wk X 4 wks), or 3) Usual and Customary Treatment (U&CT). I-ACQUIRE will be delivered by protocol-trained therapists and monitored weekly for dosage and treatment fidelity.

4) Neonatal Seizure Registry - Developmental Functional Evaluation (NSR-DEV)

Study Description

Neonatal seizures due to brain injury are associated with high risk of neurodevelopmental disability in infancy. Although prognosis in early childhood is a critical question for parents and providers, outcomes beyond infancy are generally unknown. Further, parents of infants with neonatal seizures are at risk for mental health disorders, which can undermine their ability to care for a child with medical complexity and may contribute to impaired child development. Participants will be enrolled at one of nine sites across the USA and evaluated using developmental questionnaires and in-person neurodevelopmental testing. Parent well-being will be assessed at each time point.

5) Pain Burden in Children and Adolescents with Cerebral Palsy (CPPain)

Study Description

Pain in children and adolescents with cerebral palsy (CP) is a significant health challenge that so far has received too little attention. The goal of the CPPain program is to reduce the pain experience and effects of children and adolescents living with CP. The purpose of basic data collection is to provide in-depth knowledge of the pain burden of children and adolescents with CP.This knowledge is needed to develop targeted pain-relieving interventions for this vulnerable group of children, who are burdened with the challenges associated with chronic illness. In the next step, nested intervention will be co-created with children and adolescents with CP, their parents as well as health care professionals, and other professional caregivers involved in or responsible for management of pain based on existing research and baseline findings.

North/Northeastern States (ME,VT, NH, MA, RI, CT, NJ, NY, PA, OH, IN, MI)
Map of the United States with the Northern / Northeastern States highlighted

1) Amantadine in Treating Cognitive and Motor Impairments in Adolescents and Adults with Cerebral Palsy

Study Description

Cerebral palsy (CP) is a common childhood-onset disability associated with motor and cognitive impairments, however most research is focused on motor outcomes. The aim of this study is to determine the effects of Amantadine, a dopaminergic agonist, on cognitive function in adolescents and adults with CP.

2) Immersive Virtual Reality for Visuo Motor Skill Assessment in Children with Hemiplegia

Study Description

The purpose of this study is to evaluate low-cost head mounted display virtual reality as a realistic assessment tool for visual-motor integration deficits in children with hemiplegia. The long-term goals of our research program are to: 1) Inform clinical decision-making practices by providing families and clinicians with precise, accurate information about children's abilities; and 2) Generate new knowledge about visual-motor integration impairments to enhance the effectiveness of both virtual and conventional rehabilitation interventions.

3) Home Based Tele-Exercise for People with Chronic Neurological Impairments

Study Description

This study aims to examine how effective seated Zoom exercise classes are for a person with CNI for addressing cardiovascular health, physical wellness and quality of life.  If these classes prove to be effective, online platforms could be a viable avenue for those with CNI to exercise and increase/maintain wellness without having to leave their homes. The entire process, including screening and consenting, will be done via Zoom and Redcap.

4) The Impact of Dosing Parameters on Motor Skill Acquisition and Retention in Bilateral Cerebral Palsy

Study Description

A recent systematic review found that therapeutic interventions that adopted the principles of motor learning with intensive training improved functional upper limb movement in children with unilateral CP.  The purpose of this study is to conduct a multi-center randomized control trial (RCT) to determine whether 90 hours of HABIT-ILE improves functional motor skills, activity and motivation in children with CP when dosed in a camp format at 6-hours/day, 5 days/week for three weeks and 6-hours/day, one day/week for 15 weeks.

5) Real World Testing of Brain-Computer Interface

Study Description

The goal of this project is to test a new augmentative and alternative communication brain computer interface (AAC-BCI) device comparing gel and dry electrode headgear used for communication while providing clinical care. Data on communication performance, user satisfaction, and perceptions of communication effectiveness are gathered over monthly visits along with the satisfaction and perceptions of communication effectiveness by the family support persons.

South/Southeastern States (VA, WV, KY, DE, MD, TN, AL, MS, NC, SC, GA, FL)
Map of the United States with the Southern States highlighted in purple

1. Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study in Adults

Study Description

The primary aim of this study is to determine the effects of a 12-week M2M program on health and fitness in participants with physical/mobility disabilities.The secondary aim is to compare the results to a previous M2M study that groups participants based on disability type rather than functional mobility. The third aim is to consider adherence (defined as attendance to the 12-week program) as a variable that could affect results.



2) Short-Burst Interval Treadmill Training Cerebral Palsy

Study Description

Ambulatory children with cerebral palsy (CP) walk predominately in low intensity stride rates with little variability, thus limiting walking activity and ability to participate in daily life. In contrast, typically developing (TD) children engage in short bursts of intense walking activity interspersed with varying intervals of low intensity walking within daily life. The proposed research will be the first step in a continuum of research that is expected to direct locomotor training protocols and rehab strategies across pediatric disabilities and positively affect walking performance and mobility for children with CP.

3) I-C-Fun In Children with Cerebral Palsy

Study Description

Our previous study proved that when paired with strength training, remote limb ischemic conditioning (RLIC) improves muscle strength and activation in healthy young adults and motor learning in healthy older adults. Our current work is to determine if RLIC enhances muscle power, dynamic balance, and walking performance in children with CP. This study will allow us to design and execute randomized controlled trials in children with CP as well as other neurological conditions.

Central/Northern Central States (WI, MN, IA, IL, MO, AR, LA, TX, OK, KS, NE, SD, ND)
Map of the United States with Central and North Central States highlighted in pink

1) Perinatal Stroke: Brain Reorganization During Infancy

Study Description

This will be a multiple-visit observational study done to identify possible bioindicators of recovery and repair of motor corticospinal pathways which may be targeted by future interventions in infants with perinatal stroke. Researchers will use non-invasive brain stimulation, neuroimaging, and behavioral assessments to analyze associations between development patterns and potential diagnosis of CP.

For more information, visit the Brain Recovery Study: or

2) COMET- C: Community Outreach Model of Education and Training on Communication - Focus Group

Study Description

Researchers at the Shirley Ryan Ability Lab are seeking adults with communication difficulties over 21 with cerebral palsy, and other disabilities to share their experiences interacting with businesses/service providers during a two hour focus group. The goal of the research study is to learn about participants' experiences when they communicate with said providers.

For more information please call the Center for Aphasia research at 312-238-6163 or email Elissa Larkin,

3) Stepping to Understand Lower Limb Impairments in Bilateral Cerebral Palsy

Study Description

The purpose of this study is to investigate lower limb impairments in children with bilateral cerebral palsy (BCP) during stepping tasks. Individuals with BCP sustain a neonatal brain injury that leads to altered control to the lower limbs. This can make stepping up or down a curb or stair challenging and is especially important as performance in stair-climbing is associated with limitations to overall mobility and community participation in cerebral palsy. Consenting participants will be instructed to perform multiple step-ups and step-downs on a single raised platform. The parameters of the stepping task may change by adding or subtracting weights from the body.

4) Robot Based Gait Training Therapy for Pediatric Population With Cerebral Palsy Using the CPWalker

Study Description

This trial is being conducted to determine if the CPWalker can be used as a gait training intervention for pediatric patients with gait impairments. Participants will engage in an 8-week training program, consisting of 2-3 sessions per week based on the level of gait impairment. Percentage range of motion (ROM), partial body weight support (PWBS), and gait velocity are the principal parameters under variation during training. Screening, baseline, and post-training testing sessions will be conducted.

Western States (NM, CO, WY, MT, ID, UT, AZ, NV, OR, WA, CA)
Map of the United States with Western States highlighted in dark green

Western Multi-State

1) Efficacy of a Physical Therapy Intervention Targeting Sitting and Reaching for Young Children with Cerebral Palsy (START-PLAY-CP)

Study Description

Sitting Together And Reaching To Play (START-Play) targets sitting, reaching and motor-based problem solving in infancy to improve global development. Usual Care Physical Therapy (UCPT) focuses on advancing motor skills and preventing impairments. The purpose of the proposed project is to compare the efficacy of these two fully developed physical therapy interventions in 8-24 months olds with or at high risk of having Cerebral Palsy (CP).